Good quiestion Riot. I have never been a fan of 2h weapons. I just dont think our skills, without the typical 400% weapon damage bonuses, makes the higher damage of a 2 handed weapon more effective then dual wielding. At lvl 50, I can do an extra 70-80 per strike with Iron Hands, another 200-300 per strike with one of the secrets going, and another 63 per strike with Frenzied Symbiot (now stacks with Iron Hands). To me, the more times I can attack the better.
As for the weapon choice, I found that two Hands of the God King gives the same combined DPS rating as the Hand in main and the Afrit weapon in the off. I am waiting for the upgraded, upgraded version to be released.
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