They use Hand to Hand skill

Do you mean "knuckles" as in a pair of knuckle dusters? Or "knuckles" as in your own clenched fist?

There is a specialisation for Fist Wraps, and a specialisation for Ulak and Claws, both of which are governed by Hand to Hand skills.  I am lead to believe that using a bare fist instead of a weapon will mean you lose any weapon specialisation bonus, however an empty fist is considered a "rare" weapon that scales with your level.  So if you have crap weapons, you might well be better off with no weapon equipped at all!

I wouldn't mind seeing the stats for bare fist fighting show up in the empty weapon slot so it can be properly compared.

Atelic Sceadugenga

Skill in the weapon type makes a difference.  If you have a better weapon, but only 1 skill, it will almost certainly show lower DPS.  I know this because I'm working up my skills now =P

Just a quick FYI.  Droxui pulls the dps number from the equipment page.. it doesnt calculate it.  If you mouse over the damage in the bottom right of equipment page its the same number.   hehe, which i dont really trust anyway.

Anyone know of a UI that actually calculates dps while you fight??   would go along way towards figuring out what weapon combos are actually better.